Lottery officials said the winning ticket from Friday night's drawing - worth $270 million - was sold in Portal, which is west of Statesboro in east Georgia.
In addition to the grand prize winner, 36 players matched all five numbers but not the Mega Ball number. They will receive second prizes of $250,000 each.
Another 207 players matched four numbers, plus the Mega Ball number - good for third prizes of $10,000 each.
Six California players matched five numbers, and another 38 matched four of the five lotto numbers, plus the Mega Ball number. The prize amounts in California are different than what prize winners in the other Mega Ball participating states would receive.
The next drawing - worth $12 million - will be Tuesday.
The winning numbers from Friday night's drawing were: 7, 12, 13, 19 and 22. The Mega Ball number was 10.