Tasha Humphrey and Megan Darrah scored 17 points apiece to lead the Lady Bulldogs.
In the process, Humphrey moved past Teresa Edwards into the No. 5 position among Georgia’s career scoring leaders.
Humphrey upped her point tally in a Lady Bulldog uniform to 1,995, five shy of becoming UGA’s fifth career 2,000-point scorer.
Christina Wirth scored 16 points and Hannah Tuomi added 14, all in the first 11:26 of the game.
Georgia missed its first four shots of the game and committed eight turnovers during the span.
During that span the Commodores raced to a 16-0 lead before Danielle Taylor finally broke the drought at the 10:44 mark of the first half.
Vanderbilt entered the locker room at haltime with a 38-21 lead and maintained that advantage for the first 10 minutes of the second half before the Lady Bulldogs finally made a push.
A three-pointer from Angela Puleo at the 7:22 mark ignited a 7-0 run.
Georgia pulled within six points at 57-51 on a jumper by Humphrey with 4:57 remaining but Liz Sherwood connected on a three-point play to thwart the Lady Bulldogs’ rally.
The Lady Bulldogs will return to action on Sunday when they host Alabama at 5:00 p.m. at Stegeman Coliseum. The first 1,000 youth in will receive a growth chart featuring three-time All-American and Gainesville graduate Tasha Humphrey.