Hall County Fire Chief David Kimbrell said the crash occurred about 4 p.m. on U.S. 129 near Turner's Produce, about a half-mile from the White County line.
The road was being shut down temporarily for a helicopter to land and taken the injured woman to Grady Memorial Hospital.
Another injured passenger was being taken to Northeast Georgia Medical Center by ambulance.
Additional information was not immediately available. The Georgia State Patrol is investigating.